Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar

Studies in group IV organometallic chemistry XXXI. Organotin hydride adducts with tin atoms in α,β- or β,β-positions

The structure of several organotin hydride adducts which previously were assumed to contain tin atoms in β,α-positions (β-addition followed by α-addition) has been reinvestigated. As appeared from NMR spectroscopy the greater part of these linear molecules, polymers and heterocycles are in fact β,β-adducts. Mechanistic aspects of the formation of these compounds have been discussed

Studies in group IV organometallic chemistry XXIV. Structure of products obtained in the hydrostannation of ethynes

Organotin monohydrides were brought into reaction with a variety of mono- and disubstituted ethynes. The identity of the resulting products was established by means of elementary analysis, infrared absorption spectroscopy and proton magnetic resonance spectroscopy. In the hydrostannation of monosubstituted ethynes both α- and β- adducts are formed. Electron-withdrawing sustituents favour the formation of α-adducts. In the formation of the β-adducts, as well as in the hydrostannation of disubstituted ethynes, trans-addition seems to be the rule

Studies in group VI organometallic chemistry XXV. Necleophilic trans-addtition of organotin hydrides to carbon — carbon triple bonds

Mechanistic aspects of the hydrostannation of electrophilic ethynes have been studied. As appears from stereochemical data, kinetics, and substituent, solvent and isotope effects, the addition reaction proceeds by a trans-mechanism in which nucleophilic attack of the hydride hydrogen on carbon is the first and rate-determining step. In the hydrostannation of diethyl ethynedicarboxylate most probably a five-membered cyclic transition state is involved

Studies in group IV organometallic chemistry XXVII. Isomerization of the primary trans-addition products formed in the hydrostannation of ethynes

The isomerization of the primary trans-addition products formed in the hydrostannation of ethynes has been shown to proceed under the influence of organotin radicals. Attack of such radicals on the carbon-carbon double bond produces an ethyl radical containing two organotin groups. Elimination of one of the organotin moieties as a radical may result in the formation of the isomerized product. The course of the latter step is determined by several factors. One of these seems to be a preference for those conformers of the free radical intermediate in which both tin atoms at the β-carbon atom are in gauche-position with respect to the polar substituent at the α-carbon atom. At the same time these studies reveal that in hydrostannations of certain carbon-carbon double bonds the hydrogen transfer, following the reversible attack of an organotin radical, is the rate-determining step in the propagation reaction

Synthesis and properties of some 2-(dimethylamino)methyl-substituted arylcopper compounds

The synthesis and isolation of 2-[(dimethylamino)methyl]phenylcopper and its 5-methyl, 5-methoxy, 5-chloro and 3-chloro derivatives are described. These hydrocarbon-soluble arylcopper compounds are appreciably more thermally stable than phenylcopper (e.g. 2-[(dimethylamino)methyl]phenylcopper decomposes only at 175–185°). They also show improved hydrolytic and oxidative stability. Lithiation of 1-methoxy-4-[(dimethylamino)methyl]naphthalene with butyllithium occurs at the 5-position. Metathesis of 1-methoxy-4-[(dimethylamino)methyl]-5-lithionaphthalene with cuprous bromide affords the corresponding organocopper compound

Stable arylsilver compounds containing dimethylamino, (dimethylamino)methyl or methoxy groups at the aryl nucleus

The following organosilver compounds have been prepared from the corresponding lithium compounds and silver bromide : {2-[(dimethylamino)methyl]phenyl}silver, {2-[(dimethylamino)methyl]phenyl}silver.silver bromide, bis{[2-(dimethylamino)phenyl]silver} . silver bromide, (2, 6-dimethoxyphenyl)silver and (2,4,6-trimethoxyphenyl)silver. These substituted phenylsilvers, which have been characterized by elemental analysis, mol. wt. determinations, IR and PMR spectroscopy and by degradation reactions, show greater thermal, oxidative and hydrolytic stability than phenylsilver. In general the compounds decompose between 100}o{ and 200}o{ and react slowly with oxygen and water